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KMID : 1059520080520030257
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Journal of the Korean Chemical Society
2008 Volume.52 No. 3 p.257 ~ p.265
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Synthesis, Characterization and Bioevaluation of New Tetrahydroquinazolines
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Murthy Y. L. N.
Acharyulu P. V. N.
Dubey P. K.
Tirunala Sundari T.
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Abstract
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The synthesis, characterization and bioevaluation of five new tetrahydroquinazolines was reported. Initially cyclohexanones were prepared and they were used as synthons to get the target molecules. These were condensed with substituted benzaldehydes and the resulting chalcones were treated with guanidine hydrochloride . All the molecules were non-toxic to human cells and showed significant antibacterial activity.
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KEYWORD
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Tetrahydroquinazolines, Cyclohexanones, Non-toxic Antibacterial Agents
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